PT613. The Role of SKA2 Genetic and Epigenetic Variation in Obsessive-Compulsive Disorder

s | 25 each). MB test was applied 30 min after i.p. drug administrations. In the marble burying test, 20 glass marbles, each about 4 cm apart, are arrayed on the surface of 5 cm thick sawdust bedding. The number of marbles buried (to 2/3 their depth) in a 30 min session were counted. Open field test was also conducted for locomotor activity. One-way analysis of variance (ANOVA) was used for statistical analysis followed by Tukey’s test. Results: The number of marbles buried was not significantly different in agmatine (p>0.05) or ketamine (p>0.05) alone groups compared to control. When combined together in the same dosage regimen, the number of marbles buried was statistically less than control group (p<0.05). Conclusions: When administered alone at sub-effective doses, neither ketamine nor agmatine reduced compulsive-like behaviors. However, the combination of them resulted in potantialization in anticompulsive-like effects. It could be of interest to identify shared or distinct mechanisms of these molecules possibly responsible for the proposed behavioral manifestation seen in this compulsive model.